The command line parameters sageset & sagerun still work in Vista. You can set it to delete files from a previous Windows installation, error dump files, Temporary Windows installation files, Thumbnails, Files discarded by Windows upgrade, Error Reporting Files, ect. Note: It performs a Disc Cleanup on all disks.
You can use the shortcut in the attached zip file or create a new shortcut with this command line:
%SystemRoot%\System32\Cmd.exe /c Cleanmgr /sageset:65535 & Cleanmgr /sagerun:65535
Edit the shortcut (Right click and select Properties), set it to run Minimized and change the Icon to %SystemRoot%\System32\Cleanmgr.exe.